|
T1566 |
Aripiprazole
|
OPC-14597 |
5-HT Receptor
|
|
Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a... |
|
T2150 |
Guanfacine hydrochloride
|
Tenex,Intuniv,Guanfacine |
Adrenergic Receptor
|
|
Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS. |
|
T4297 |
Flibanserin
|
BIMT-17BS,Girosa,BIMT-17 |
Dopamine Receptor
,
5-HT Receptor
|
|
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n... |
|
T13007 |
ST1936 oxalate
|
|
5-HT Receptor
|
|
ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively). |
|
T27252 |
ELB-139
|
ELB139 |
|
|
ELB-139 is a GABA A receptor agonist. ELB139 increases 5-HT in the striatum and prefrontal cortex of rats. |
|
T14083 |
Abaperidone
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th... |
|
T26564 |
ADCI
|
SGB-017,SGB017,SGB 017 |
|
|
ADCI is an inhibitor of voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabo... |
|
TP2067 |
Cortagine
|
|
|
|
Potent and selective corticotrophin releasing factor receptor 1 (CRF1) agonist (EC50 = 0.18 nM for rat CRF1). Displays anxiolytic and antidepressant activity in vivo. Microinfusion into mouse prefrontal cortex reduces de... |
|
T73359 |
NYX-2925
|
|
|
|
NYX-2925, an orally active NMDAR (N-methyl-D-aspartate receptor) modulator, enhances activated Src levels and Src phosphorylation at GluN2A and GluN2B sites in the mPFC (medial prefrontal cortex), without affecting CAMKI... |
